Optimal management of UCDs requires a comprehensive approach to nutrition education and support that evolves across the lifespan. Developmentally appropriate education improves understanding, fosters self-management, and should be adapted to the individual’s cognitive and social context. Families benefit from practical, hands-on training in daily management and emergency protocols, with support tailored to cultural and logistical needs. Behavioral interventions effectively address feeding difficulties, supporting safer oral intake and reducing caregiver stress. As patients transition into adolescence and adulthood, targeted education must address real-life risks, treatment burden, and emotional well-being, while preparing for adult care transitions. Finally, leveraging digital tools, peer networks, and coordinated multidisciplinary care enhances access to education, fosters connection, and strengthens adherence across all stages of life.